Article
Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs.
Human mutation - 1 Nov 2015
Cavadas Bruno, Soares Pedro, Camacho Rui, Brandão Andreia, Costa Marta D, Fernandes Verónica, Pereira Joana B, Rito Teresa, Samuels David C, Pereira Luisa
Abstract excerpt
A high-resolution mtDNA phylogenetic tree allowed us to look backward in time to investigate purifying selection. Purifying selection was very strong in the last 2,500 years, continuously eliminating pathogenic mutations back until the end of the Younger Dryas (∼11,000 years ago), when a large population expansion likely relaxed selection pressure. This was preceded by a phase of stable selection until another...
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