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Article

Correcting for purifying selection: an improved human mitochondrial molecular clock.

American journal of human genetics - 1 Jun 2009

Soares Pedro, Ermini Luca, Thomson Noel, Mormina Maru, Rito Teresa, Röhl Arne, Salas Antonio, Oppenheimer Stephen, Macaulay Vincent, Richards Martin B

Abstract excerpt

There is currently no calibration available for the whole human mtDNA genome, incorporating both coding and control regions. Furthermore, as several authors have pointed out recently, linear molecular clocks that incorporate selectable characters are in any case problematic. We here confirm a modest effect of purifying selection on the mtDNA coding region and propose an improved molecular clock for dating human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19500773
DOI: 10.1016/j.ajhg.2009.05.001
PMCID: PMC2694979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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