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Article

A Human Cell Line Model for Interferon-α Driven Dendritic Cell Differentiation.

PloS one - 1 Jan 2015

Ruben Jurjen M, Visser Lindy L, Heinhuis Kimberley M, O'Toole Tom, Bontkes Hetty J, Westers Theresia M, Ossenkoppele Gert J, de Gruijl Tanja D, van de Loosdrecht Arjan A

Abstract excerpt

The CD34+ MUTZ-3 acute myeloid leukemia cell line has been used as a dendritic cell (DC) differentiation model. This cell line can be cultured into Langerhans cell (LC) or interstitial DC-like cells using the same cytokine cocktails used for the differentiation of their primary counterparts. Currently, there is an increasing interest in the study and clinical application of DC generated in the presence of IFNα,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26252775
DOI: 10.1371/journal.pone.0135219
PMCID: PMC4529224

Genes

CCL21
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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