Article
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.
The Journal of experimental medicine - 7 Jun 2010
Poulin Lionel Franz, Salio Mariolina, Griessinger Emmanuel, Anjos-Afonso Fernando, Craciun Ligia, Chen Ji-Li, Keller Anna M, Joffre Olivier, Zelenay Santiago, Nye Emma, Le Moine Alain, Faure Florence, Donckier Vincent, Sancho David, Cerundolo Vincenzo, Bonnet Dominique, Reis e Sousa Caetano
Abstract excerpt
In mouse, a subset of dendritic cells (DCs) known as CD8alpha+ DCs has emerged as an important player in the regulation of T cell responses and a promising target in vaccination strategies. However, translation into clinical protocols has been hampered by the failure to identify CD8alpha+ DCs in humans. Here, we characterize a population of human DCs that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and...
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