Article
A rapid culture technique produces functional dendritic-like cells from human acute myeloid leukemia cell lines.
Journal of biomedicine & biotechnology - 1 Jan 2011
Ning Jian, Morgan David, Pamphilon Derwood
Abstract excerpt
Most anti-cancer immunotherapeutic strategies involving dendritic cells (DC) as vaccines rely upon the adoptive transfer of DC loaded with exogenous tumour-peptides. This study utilized human acute myeloid leukemia (AML) cells as progenitors from which functional dendritic-like antigen presenting cells (DLC) were generated, that constitutively express tumour antigens for recognition by CD8(+) T cells. DLC were...
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