Article
Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele.
Birth defects research. Part A, Clinical and molecular teratology - 1 Sept 2015
Mazumdar Maitreyi, Valeri Linda, Rodrigues Ema G, Ibne Hasan Md Omar Sharif, Hamid Rezina, Paul Ligi, Selhub Jacob, Silva Fareesa, Mostofa Md Golam, Quamruzzaman Quazi, Rahman Mahmuder, Christiani David C
Abstract excerpt
BACKGROUND: Arsenic induces neural tube defects in many animal models. Additionally, studies have shown that mice with specific genetic defects in folate metabolism and transport are more susceptible to arsenic-induced neural tube defects. We sought to determine whether 14 single-nucleotide polymorphisms in genes involved in folate metabolism modified the effect of exposure to drinking water contaminated with...
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