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Article

Evidence of gene-gene interactions between MTHFD1 and MTHFR in relation to anterior encephalocele susceptibility in Northeast India.

Birth defects research - 3 Apr 2017

Dutta Hemonta Kr, Borbora Debasish, Baruah Mauchumi, Narain Kanwar

Abstract excerpt

BACKGROUND: Anterior encephalocele (AE) is a rare congenital anomaly of the central nervous system which is thought to be associated with genetic defects in folate metabolism. METHODS: This case-control study investigated the interactions of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1)-1958G>A (rs2236225) and the methylenetetrahydrofolate reductase (MTHFR) - 677C>T (rs1801133) and 1298A>C (rs1801131)...

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Share to Asian People
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Share to Epistasis, Genetic
Share to Genetic Testing
Share to India
Share to Methylenetetrahydrofolate Dehydrogenase (NADP)
Share to Methylenetetrahydrofolate Reductase (NADPH2)
Share to Minor Histocompatibility Antigens

Source

Identifiers

PMID: 28398708
DOI: 10.1002/bdra.23607

Genes

MTHFR
MTHFD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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