Article
Maternal arsenic exposure modifies associations between arsenic, folate and arsenic metabolism gene variants, and spina bifida risk: A case‒control study in Bangladesh.
Environmental research - 15 Nov 2024
Wei Chih-Fu, Tindula Gwen, Mukherjee Sudipta Kumer, Wang Xingyan, Ekramullah Sheikh Muhammad, Arman D M, Islam Md Joynul, Azim Mubinul, Rahman Asifur, Afreen Shamantha, Ziaddin Md, Warf Benjamin C, Weisskopf Marc G, Christiani David C, Liang Liming, Mazumdar Maitreyi
Abstract excerpt
BACKGROUND: Spina bifida is a type of neural tube defect (NTD); NTDs are developmental malformations of the spinal cord that result from failure of neural tube closure during embryogenesis and are likely caused by interactions between genetic and environmental factors. Arsenic induces NTDs in animal models, and studies demonstrate that mice with genetic defects related to folate metabolism are more susceptible to...
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