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Article

Maternal gene-micronutrient interactions related to one-carbon metabolism and the risk of myelomeningocele among offspring.

Birth defects research - 30 Jan 2017

Nguyen Margaret P, Lupo Philip J, Northrup Hope, Morrison Alanna C, Cirino Paul T, Au Kit Sing

Abstract excerpt

BACKGROUND: Few studies have evaluated interactions between maternal genetic variation in 5,10-methylenetetrahydrofolate reductase (MTHFR) and micronutrient intake on the risk of myelomeningocele (MM) in offspring. Therefore, we sought to determine if the role of maternal MTHFR C677T and A1298C on MM risk is altered by maternal intake of micronutrients related to one-carbon metabolism. METHODS: The study...

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Source

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Identifiers

PMID: 27384413
DOI: 10.1002/bdra.23538
PMCID: PMC5250578

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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