Article
Better allele-level matching improves transplant-related mortality after double cord blood transplantation.
Haematologica - 1 Oct 2015
Oran Betül, Cao Kai, Saliba Rima M, Rezvani Katayoun, de Lima Marcos, Ahmed Sairah, Hosing Chitra M, Popat Uday R, Carmazzi Yudith, Kebriaei Partow, Nieto Yago, Rondon Gabriela, Willis Dana, Shah Nina, Parmar Simrit, Olson Amanda, Moore Brandt, Marin David, Mehta Rohtesh, Fernández-Viña Marcelo, Champlin Richard E, Shpall Elizabeth J
Abstract excerpt
Cord blood transplant requires less stringent human leukocyte antigen matching than unrelated donors. In 133 patients with hematologic malignancies who engrafted after double cord blood transplantation with a dominant unit, we studied the effect of high resolution testing at 4 loci (-A, -B, -C, -DRB1) for its impact on 2-year transplant-related mortality. Ten percent of the dominant cord blood units were matched...
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