Article
Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome.
Blood - 1 Oct 2004
Flomenberg Neal, Baxter-Lowe Lee Ann, Confer Dennis, Fernandez-Vina Marcelo, Filipovich Alexandra, Horowitz Mary, Hurley Carolyn, Kollman Craig, Anasetti Claudio, Noreen Harriet, Begovich Ann, Hildebrand William, Petersdorf Effie, Schmeckpeper Barbara, Setterholm Michelle, Trachtenberg Elizabeth, Williams Thomas, Yunis Edmond, Weisdorf Daniel
Abstract excerpt
Outcome of unrelated donor marrow transplantation is influenced by donor-recipient matching for HLA. Prior studies assessing the effects of mismatches at specific HLA loci have yielded conflicting results. The importance of high-resolution matching for all HLA loci has also not been established. We therefore examined the effects of HLA matching (low or high resolution or both) on engraftment, graft-versus-host...
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