Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphism rs4263535 in GABRA1 intron 4 was related to deeper sedation by intravenous midazolam.

The Journal of international medical research - 1 Oct 2015

Choi Yoon-Ji, Lee Shin Yuong, Yang Kyung-Sook, Park Ji-Young, Yoon Seung Zhoo, Yoon Suk Min

Abstract excerpt

OBJECTIVE: To evaluate whether polymorphisms in the gamma-aminobutyric acid A receptor α1 subunit (GABRA1) gene influence sleep induction time, bispectral index score (BIS) during sleep induction and the total dose of midazolam required to reach a Ramsay Sedation Assessment Scale (RSAS) score of 4. METHODS: Patients scheduled for elective orthopaedic surgery were enrolled. All patients received initial doses of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Introns

Share to Logistic Models

Share to Midazolam

Share to Polymorphism, Single Nucleotide

Share to Receptors, GABA-A

Share to Statistics, Nonparametric

Source

Identifiers

PMID: 26249742
DOI: 10.1177/0300060515587580

Genes

GABRA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphism rs4263535 in GABRA1 intron 4 was related to deeper sedation by intravenous midazolam.PMID 26249742Read ↗

γ-Aminobutyric acid type A receptor β1 subunit gene polymorphisms are associated with the sedative and amnesic effects of midazolam.Semantic proximity Read ↗

The pharmacogenetics of medications used in general anesthesia.Semantic proximity Read ↗

Gamma-aminobutyric acid (GABA) receptors GABRA4, GABRE, and GABRQ gene polymorphisms and risk for migraine.Semantic proximity Read ↗

A single nucleotide polymorphism-based formula to predict the risk of propofol TCI concentration being over 4 µg mL-1 at the time of loss of consciousness.Semantic proximity Read ↗

Association of GABA(B)R1 receptor gene polymorphism with obstructive sleep apnea syndrome.Semantic proximity Read ↗

An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population.Semantic proximity Read ↗

Interaction between γ-aminobutyric acid A receptor genes: new evidence in migraine susceptibility.Semantic proximity Read ↗

Pharmacogenetics and anesthetic drugs.Semantic proximity Read ↗

Experimental Evaluation of ABCB1 C3435T (rs1045642) Gene Polymorphism and Its Association with Postoperative Analgesia in Hip Replacement Surgery.Semantic proximity Read ↗

Effect of A118G (rs1799971) single-nucleotide polymorphism of the μ-opioid receptor OPRM1 gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery.Semantic proximity Read ↗

Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to hypnosis induced by isoflurane and ethanol than the wild type rats.Semantic proximity Read ↗

Genetic variation of rs12918566 affects GRIN2A expression and is associated with spontaneous movement response during sevoflurane anesthesia induction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.