Effect of A118G (rs1799971) single-nucleotide polymorphism of the μ-opioid receptor OPRM1 gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery.

doi:10.1002/npr2.12468

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Article

Effect of A118G (rs1799971) single-nucleotide polymorphism of the μ-opioid receptor OPRM1 gene on intraoperative remifentanil requirements in Japanese women undergoing laparoscopic gynecological surgery.

Neuropsychopharmacology reports - 1 Sept 2024

Zou Ruying, Nishizawa Daisuke, Inoue Rie, Hasegawa Junko, Ebata Yuko, Nakayama Kyoko, Hara Atsuko, Sumikura Hiroyuki, Kitade Mari, Hayashida Masakazu, Ikeda Kazutaka, Kawagoe Izumi

Abstract excerpt

AIM: Abundant data are available on the effect of the A118G (rs1799971) single-nucleotide polymorphism (SNP) of the μ-opioid receptor OPRM1 gene on morphine and fentanyl requirements for pain control. However, data on the effect of this SNP on intraoperative remifentanil requirements remain limited. We investigated the effect of this SNP on intraoperative remifentanil requirements. METHODS: We investigated 333...

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PMID: 39093709
DOI: 10.1002/npr2.12468
PMCID: PMC11544447

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OPRM1

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