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Article

Structure of BbKI, a disulfide-free plasma kallikrein inhibitor.

Acta crystallographica. Section F, Structural biology communications - 1 Aug 2015

Zhou Dongwen, Hansen Daiane, Shabalin Ivan G, Gustchina Alla, Vieira Debora F, de Brito Marlon V, Araújo Ana Paula U, Oliva Maria Luiza V, Wlodawer Alexander

Abstract excerpt

A serine protease inhibitor from Bauhinia bauhinioides (BbKI) belongs to the Kunitz family of plant inhibitors, which are common in plant seeds. BbKI does not contain any disulfides, unlike most other members of this family. It is a potent inhibitor of plasma kallikrein, in addition to other serine proteases, and thus exhibits antithrombotic activity. A high-resolution crystal structure of recombinantly expressed...

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Identifiers

PMID: 26249699
DOI: 10.1107/S2053230X15011127
PMCID: PMC4528941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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