Article
HV-BBI--a novel amphibian skin Bowman-Birk-like trypsin inhibitor.
Biochemical and biophysical research communications - 18 Jul 2008
Song Ganhong, Zhou Mei, Chen Wei, Chen Tianbao, Walker Brian, Shaw Chris
Abstract excerpt
Here we describe the isolation of a novel C-terminally amidated octadecapeptide--SVIGCWTKSIPPRPCFVK-amide--that contains a disulphide loop between Cys(5) and Cys(15) that is consistent with a Bowman-Birk type protease inhibitor, from the skin secretion of the Chinese Bamboo odorous frog, Huia versabilis. Named HV-BBI, the peptide is encoded by a single precursor of 62 amino acid residues whose primary structure...
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