Article
Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI.
Acta crystallographica. Section D, Structural biology - 1 Aug 2021
Li Mi, Srp Jaroslav, Mareš Michael, Wlodawer Alexander, Gustchina Alla
Abstract excerpt
Structures of BbKI, a recombinant Kunitz-type serine protease inhibitor from Bauhinia bauhinioides, complexed with human kallikrein 4 (KLK4) were determined at medium-to-high resolution in four crystal forms (space groups P3121, P6522, P21 and P61). Although the fold of the protein was virtually identical in all of the crystals, some significant differences were observed in the conformation of Arg64 of BbKI, the...
Topics
- Bauhinia
- Kallikreins
- Mutation
- Plant Proteins
- Protein Binding