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Article

Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.

Aging cell - 1 Aug 2023

Mak Jonathan K L, Kananen Laura, Qin Chenxi, Kuja-Halkola Ralf, Tang Bowen, Lin Jake, Wang Yunzhang, Jääskeläinen Tuija, Koskinen Seppo, Lu Yi, Magnusson Patrik K E, Hägg Sara, Jylhävä Juulia

Abstract excerpt

Identifying metabolic biomarkers of frailty, an age-related state of physiological decline, is important for understanding its metabolic underpinnings and developing preventive strategies. Here, we systematically examined 168 nuclear magnetic resonance-based metabolomic biomarkers and 32 clinical biomarkers for their associations with frailty. In up to 90,573 UK Biobank participants, we identified 59 biomarkers...

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Identifiers

PMID: 37184129
DOI: 10.1111/acel.13868
PMCID: PMC10410014

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