Article
Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study.
Experimental gerontology - 1 Sept 2004
van den Biggelaar Anita H J, Huizinga Tom W J, de Craen Anton J M, Gussekloo Jacobijn, Heijmans Bastiaan T, Frölich Marijke, Westendorp Rudi G J
Abstract excerpt
Aging is associated with an impaired capacity of the immune system to respond properly to danger signals, such as infection and cancer. Here, we provide evidence that an impaired innate immune response, as measured by a low production capacity of pro- and anti-inflammatory cytokines upon ex vivo standardized danger signalling with bacterial LPS, is predictive for frailty in elderly people: participants who at age...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.