Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila.

Disease models & mechanisms - 1 Oct 2017

Mao Chuan-Xi, Wen Xue, Jin Shan, Zhang Yong Q

Abstract excerpt

Tau normally associates with and stabilizes microtubules (MTs), but is hyperphosphorylated and aggregated into neurofibrillary tangles in Alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies. MTs are regulated by different forms of post-translational modification, including acetylation; acetylated MTs represent a more stable microtubule population. In our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Microtubules

Share to Neuromuscular Junction

Share to tau Proteins

Share to Tauopathies

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 28819043
DOI: 10.1242/dmm.028316
PMCID: PMC5665452

Genes

HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila.PMID 28819043Read ↗

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.Semantic proximity Read ↗

Mutating different α-tubulin acetylation sites has distinct effects on axon terminal morphogenesis in Drosophila melanogaster.Semantic proximity Read ↗

Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicitySemantic proximity Read ↗

αTAT1 is the major α-tubulin acetyltransferase in mice.Semantic proximity Read ↗

HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesSemantic proximity Read ↗

MeCP2 deficiency is associated with reduced levels of tubulin acetylation and can be restored using HDAC6 inhibitors.Semantic proximity Read ↗

An acetylation-phosphorylation switch that regulates tau aggregation propensity and function.Semantic proximity Read ↗

Effects of mutating α-tubulin lysine 40 on sensory dendrite development.Semantic proximity Read ↗

N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eyeSemantic proximity Read ↗

Restoring the Balance: CRISPRa-Driven β-Tubulin Compensation as a Strategy for Tubulinopathy Treatment.Semantic proximity Read ↗

Crosstalk between acetylation and the tyrosination/detyrosination cycle of α-tubulin in Alzheimer’s diseaseSemantic proximity Read ↗

HDAC6 inhibition as a mechanism to prevent neurodegeneration in the mSOD1G93A mouse model of ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.