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Article

Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice.

Oncotarget - 10 May 2016

Ran Jie, Yu Fan, Qin Juan, Zhang Yijun, Yang Yunfan, Li Dengwen, Zhou Jun, Liu Min

Abstract excerpt

Cilia are present in most vertebrate tissues with a wide variety of functions, and abnormalities of cilia are linked to numerous human disorders. However, the molecular events underlying ciliary homeostasis are poorly understood. In this study, we generated double knockout (DKO) mice for the deubiquitinase cylindromatosis (CYLD) and histone deacetylase 6 (HDAC6), two critical ciliary regulators. The Cyld/Hdac6...

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Source

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Identifiers

PMID: 27028867
DOI: 10.18632/oncotarget.8374
PMCID: PMC5053669

Genes

HDAC6
CYLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice.PMID 27028867Read ↗

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