Article
A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation.
International journal of hematology - 1 Oct 2015
Nomoto Haruka, Takami Akiyoshi, Espinoza J Luis, Matsuo Keitaro, Mizuno Shohei, Onizuka Makoto, Kashiwase Koichi, Morishima Yasuo, Fukuda Takahiro, Kodera Yoshihisa, Doki Noriko, Miyamura Koichi, Mori Takehiko, Nakao Shinji, Ohtake Shigeki, Morishita Eriko
Abstract excerpt
Thrombomodulin, encoded by the THBD gene, is a critical regulator of coagulation and innate immunity. Its gene variant (rs3176123, 2729A>C) in the 3' untranslated region has been reported to be associated with vasculopathies. The present study analyzed the impact of THBD variation on transplant outcomes in a cohort of 317 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.