Article
Early Elevation of Complement Factor Ba Is a Predictive Biomarker for Transplant-Associated Thrombotic Microangiopathy.
Frontiers in immunology - 1 Jan 2021
Okamura Hiroshi, Nakamae Hirohisa, Shindo Takero, Ohtani Katsuki, Hidaka Yoshihiko, Ohtsuka Yasufumi, Makuuchi Yosuke, Kuno Masatomo, Takakuwa Teruhito, Harada Naonori, Nishimoto Mitsutaka, Nakashima Yasuhiro, Koh Hideo, Hirose Asao, Nakamae Mika, Wakamiya Nobutaka, Hino Masayuki, Inoue Norimitsu
Abstract excerpt
Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Previous reports suggest that TA-TMA is caused by complement activation by complement-related genetic variants; however, this needs to be verified, especially in adults. Here, we performed a nested case-control study of allo-HSCT-treated adults at a single center....
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