Pretransplant Genetic Susceptibility: Clinical Relevance in Transplant-Associated Thrombotic Microangiopathy.

doi:10.1055/s-0040-1702225

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Article

Pretransplant Genetic Susceptibility: Clinical Relevance in Transplant-Associated Thrombotic Microangiopathy.

Thrombosis and haemostasis - 1 Apr 2020

Gavriilaki Eleni, Touloumenidou Tasoula, Sakellari Ioanna, Batsis Ioannis, Mallouri Despina, Psomopoulos Fotis, Tsagiopoulou Maria, Koutra Maria, Yannaki Evangelia, Papalexandri Apostolia, Taylor Pat, Nikolousis Emmanuel, Stamouli Maria, Holbro Andreas, Baltadakis Ioannis, Liga Maria, Spyridonidis Alexandros, Tsirigotis Panagiotis, Charchalakis Nikolaos, Tsakiris Dimitrios A, Brodsky Robert A, Passweg Jacob, Stamatopoulos Kostas, Anagnostopoulos Achilles

Abstract excerpt

Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical outcomes. We studied 40 patients with TA-TMA, donors of 18 patients and 40 control non-TMA HCT...

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PMID: 32131130
DOI: 10.1055/s-0040-1702225

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