Article
The CD28 IVS3 + 17 T/C polymorphism and the GVHD occurrence in Tunisian patients receiving an HLA-identical sibling HSCs transplant.
Human immunology - 1 Sept 2024
Ghazouani Eya, Sellami Mohamed Hichem, Aissa Wafa, Ben Abdeljelil Nour, Chaabane Manel, Kaabi Houda, Ben Othman Tarek, Hmida Slama
Abstract excerpt
Graft-versus-host disease (GVHD) is a potentially serious complication ofallogeneic hematopoietic stem cell transplantation (HSCT). Graft-contaminating T cells (donor T cells) arecrucial for the development ofGVHD since they are able to react against the recipient's antigens. In this study we aim toevaluatethepotentialassociation between the IVS3 + 17 T/C gene variation in the CD28 molecule, a T cells...
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