Article
Double-stranded RNA evokes exacerbation in a mouse model of corticosteroid refractory asthma.
Clinical science (London, England : 1979) - 1 Dec 2015
De Alba Jorge, Otal Raquel, Calama Elena, Domenech Anna, Prats Neus, Gozzard Neil, Miralpeix Montserrat
Abstract excerpt
RNA viruses are a major cause of respiratory infections and are known to exacerbate asthma and other respiratory diseases. Our aim was to test the ability of poly(I:C) (polyinosinic:polycytidylic acid), a viral surrogate, to elicit exacerbation in a model of severe asthma driven by HDM (house dus...
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