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Article

Double-stranded RNA induces molecular and inflammatory signatures that are directly relevant to COPD

19 Sept 2012

Abstract excerpt

Polyinosinic:polycytidylic acid (poly I:C) is a synthetic analogue of double-stranded (ds)RNA, a molecular pattern associated with viral infections, that is used to exacerbate inflammation in lung injury models. Despite its frequent use, there are no detailed studies of the responses elicited by a single topical administration of poly I:C to the lungs of mice. Our data provides the first demonstration that the...

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PMID: 22990623
DOI: 10.1038/mi.2012.86

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