Article

Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma

2023-11-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Prostaglandin D2 (PGD2) signals via the DP1 and DP2 receptors. In Phase II trials, DP2 antagonism decreased airway inflammation and airway smooth muscle (ASM) area in patients with moderate-to-severe asthma, but in the Phase III clinical trials, DP2 antagonism failed to significantly lower the rate of exacerbations. Here, we hypothesised that DP2 antagonism resolves establis...

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Literature Corpus work: 3def7d58-5ad0-50e1-8a93-838afd9578ba
DOI: 10.1101/2023.11.12.566772

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