Article
Crystal structures of ryanodine receptor SPRY1 and tandem-repeat domains reveal a critical FKBP12 binding determinant.
Nature communications - 6 Aug 2015
Yuchi Zhiguang, Yuen Siobhan M Wong King, Lau Kelvin, Underhill Ainsley Q, Cornea Razvan L, Fessenden James D, Van Petegem Filip
Abstract excerpt
Ryanodine receptors (RyRs) form calcium release channels located in the membranes of the sarcoplasmic and endoplasmic reticulum. RyRs play a major role in excitation-contraction coupling and other Ca(2+)-dependent signalling events, and consist of several globular domains that together form a large assembly. Here we describe the crystal structures of the SPRY1 and tandem-repeat domains at 1.2-1.5 Å resolution,...
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