Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Evolutionary Potential of Phenotypic Mutations.

PLoS genetics - 1 Aug 2015

Yanagida Hayato, Gispan Ariel, Kadouri Noam, Rozen Shelly, Sharon Michal, Barkai Naama, Tawfik Dan S

Abstract excerpt

Errors in protein synthesis, so-called phenotypic mutations, are orders-of-magnitude more frequent than genetic mutations. Here, we provide direct evidence that alternative protein forms and phenotypic variability derived from translational errors paved the path to genetic, evolutionary adaptations via gene duplication. We explored the evolutionary origins of Saccharomyces cerevisiae IDP3 - an NADP-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Evolution, Molecular
Share to Frameshift Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Isocitrate Dehydrogenase

Share to Peroxisomes

Share to Protein Transport

Share to Saccharomyces cerevisiae

Source

Open in PubMed Open full text

Identifiers

PMID: 26244544
DOI: 10.1371/journal.pgen.1005445
PMCID: PMC4526572

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Evolutionary Potential of Phenotypic Mutations.PMID 26244544Read ↗

Phenotypic mutations contribute to protein diversity and shape protein evolution.Semantic proximity Read ↗

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes.Semantic proximity Read ↗

A genome-to-proteome map reveals how natural variants drive proteome diversity and shape fitness.Semantic proximity Read ↗

Mistranslation: from adaptations to applications.Semantic proximity Read ↗

A high-definition view of functional genetic variation from natural yeast genomes.Semantic proximity Read ↗

Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast.Semantic proximity Read ↗

Critical roles for a genetic code alteration in the evolution of the genus Candida.Semantic proximity Read ↗

Domestication signatures in the non-conventional yeast <i>Lachancea cidri</i>Semantic proximity Read ↗

Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover.Semantic proximity Read ↗

Tracing the De Novo Origin of Protein-Coding Genes in Yeast.Semantic proximity Read ↗

Genetic code ambiguity: an unexpected source of proteome innovation and phenotypic diversity.Semantic proximity Read ↗

Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.