The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients.

doi:10.1097/QAD.0000000000000706

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The role of chemokine C-C motif ligand 2 genotype and cerebrospinal fluid chemokine C-C motif ligand 2 in neurocognition among HIV-infected patients.

AIDS (London, England) - 31 Jul 2015

Thames April D, Briones Marisa S, Magpantay Larry I, Martinez-Maza Otoniel, Singer Elyse J, Hinkin Charles H, Morgello Susan, Gelman Benjamin B, Moore David J, Heizerling Keith, Levine Andrew J

Abstract excerpt

OBJECTIVES: We examined interrelationships between chemokine C-C motif ligand 2 (CCL2) genotype and expression of inflammatory markers in the cerebrospinal fluid (CSF), plasma viral load, CD4 cell count and neurocognitive functioning among HIV-infected adults. We hypothesized that HIV-positive carriers of the 'risk' CCL2 -2578G allele, caused by a single nucleotide polymorphism (SNP) at rs1024611, would have a...

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PMID: 26244388
DOI: 10.1097/QAD.0000000000000706
PMCID: PMC4573552

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CCL2
TNF

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