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Article

A candidate gene study of intermediate histopathological phenotypes in HIV-associated neurocognitive disorders.

Journal of neurovirology - 1 Aug 2020

Levine Andrew J, Soontornniyomkij Virawudh, Masliah Eliezer, Sinsheimer Janet S, Ji Sarah S, Horvath Steve, Singer Elyse J, Kallianpur Asha, Moore David J

Abstract excerpt

HIV-associated neurocognitive disorders (HAND) describe a spectrum of neuropsychological impairment caused by HIV-1 infection. While the sequence of cellular and physiological events that lead to HAND remains obscure, it likely involves chronic neuroinflammation. Host genetic markers that increase the risk for HAND have been reported, but replication of such studies is lacking, possibly due to inconsistent...

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Identifiers

PMID: 32394397
DOI: 10.1007/s13365-020-00846-z
PMCID: PMC7442707

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