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Article

Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vessels.

The Journal of biological chemistry - 11 Apr 2014

Yi Fu, Wang Huan, Chai Qiang, Wang Xiaoli, Shen Win-Kuang, Willis Monte S, Lee Hon-Chi, Lu Tong

Abstract excerpt

The large conductance Ca(2+)-activated K(+) (BK) channel, expressed abundantly in vascular smooth muscle cells (SMCs), is a key determinant of vascular tone. BK channel activity is tightly regulated by its accessory β1 subunit (BK-β1). However, BK channel function is impaired in diabetic vessels by increased ubiquitin/proteasome-dependent BK-β1 protein degradation. Muscle RING finger protein 1 (MuRF1), a...

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Share to Coronary Vessels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 24570002
DOI: 10.1074/jbc.M113.520940
PMCID: PMC4036198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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