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Diabetic cardiomyopathy: role of the E3 ubiquitin ligase

10 Feb 2016

Abstract excerpt

Diabetic cardiomyopathy (DCM) is the leading cause of mortality in diabetes. As the number of cases of diabetes continues to rise, it is urgent to develop new strategies to protect against DCM, which is characterized by cardiac hypertrophy, increased apoptosis, fibrosis, and altered insulin metabolism. The E3 ubiquitin ligases (E3s), one component of the ubiquitin-proteasome system, play vital roles in all of the...

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PMID: 26732687
DOI: 10.1152/ajpendo.00467.2015

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