Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.

doi:10.1016/j.immuni.2014.04.011

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Article

Pattern recognition receptor signaling in human dendritic cells is enhanced by ICOS ligand and modulated by the Crohn's disease ICOSLG risk allele.

Immunity - 15 May 2014

Hedl Matija, Lahiri Amit, Ning Kaida, Cho Judy H, Abraham Clara

Abstract excerpt

Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune homeostasis and cytokine secretion. Multiple loci are associated with IBD, but a functional explanation is missing for most. Here we found that pattern-recognition receptor (PRR)-induced cytokine secretion was diminished in human monocyte-derived dendritic cells (MDDC) from rs7282490 ICOSLG GG risk carriers. Homotypic interactions...

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Identifiers

PMID: 24837102
DOI: 10.1016/j.immuni.2014.04.011
PMCID: PMC4157904

Genes

ICOS
ICOSLG
NOD2
RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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