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Proximal binding pocket Arg717 substitutions in <i>Escherichia coli</i> AcrB cause clinically relevant divergencies in resistance profiles

2021-12-19

Abstract excerpt

Multidrug resistance (MDR) in bacteria can be caused by the over-expression of multidrug efflux pumps belonging to the Resistance-Nodulation-Division (RND) superfamily of proteins. These intrinsic or acquired pumps can export a wide range of antibiotics. Recently, amino acid substitutions within these pumps have been observed in resistant clinical strains. Among others, two of these worrying gain-of-function mutat...

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Literature Corpus work
379bfaa1-059f-5bec-adbc-da62dca2ba1a
DOI
10.1101/2021.12.16.473095
Open publication

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Proximal binding pocket Arg717 substitutions in <i>Escherichia coli</i> AcrB cause clinically relevant divergencies in resistance profilesDOI 10.1101/2021.12.16.473095
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