Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.

doi:10.1016/j.jid.2016.08.015

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Article

Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.

The Journal of investigative dermatology - 1 Jan 2017

González-Vela María Del Carmen, Curiel-Olmo Soraya, Derdak Sophia, Beltran Sergi, Santibañez Miguel, Martínez Nerea, Castillo-Trujillo Alfredo, Gut Martha, Sánchez-Pacheco Roxana, Almaraz Carmen, Cereceda Laura, Llombart Beatriz, Agraz-Doblas Antonio, Revert-Arce José, López Guerrero José Antonio, Mollejo Manuela, Marrón Pablo Isidro, Ortiz-Romero Pablo, Fernandez-Cuesta Lynnette, Varela Ignacio, Gut Ivo, Cerroni Lorenzo, Piris Miguel Ángel, Vaqué José Pedro

Abstract excerpt

Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine tumor of the skin whose molecular pathogenesis is not completely understood, despite the role that Merkel cell polyomavirus can play in 55-90% of cases. To study potential mechanisms driving this disease in clinically characterized cases, we searched for somatic mutations using whole-exome sequencing, and extrapolated our findings to study...

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Identifiers

PMID: 27592799
DOI: 10.1016/j.jid.2016.08.015

Genes

MCC
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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