Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNF111/Arkadia is regulated by DNA methylation and affects TGF-β/Smad signaling associated invasion in NSCLC cells.

Lung cancer (Amsterdam, Netherlands) - 1 Oct 2015

Chen Hongbing, Yang Tianjie, Lei Zhe, Wang Longqiang, Yang Haiping, Tong Xin, Yang Wen-Tao, Zhao Jun, Gu Yunbin, Chen Yongbing, Zhang Hong-Tao

Abstract excerpt

OBJECTIVES: RNF111/Arkadia is a critical regulator of TGF-β signaling, being required for SMAD3-mediated responses such as TGF-β-induced repression of E-cadherin. Previous studies show that mutations in RNF111 in human cancers are rare and RNF111 promotes lung tumor metastasis. However, the epigenetic mechanisms underlying the role of RNF111 in non-small cell lung cancer (NSCLC) metastasis remain unknown. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Non-Small-Cell Lung
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to RNA Interference

Share to Smad3 Protein

Share to Transforming Growth Factor beta

Share to Ubiquitin-Protein Ligases

Share to Up-Regulation

Source

Identifiers

PMID: 26238425
DOI: 10.1016/j.lungcan.2015.07.010

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNF111/Arkadia is regulated by DNA methylation and affects TGF-β/Smad signaling associated invasion in NSCLC cells.PMID 26238425Read ↗

RBM10 Interacts with CTBNNBIP1 and Represses Lung Adenocarcinoma Progression Through the Wnt/β- catenin PathwaySemantic proximity Read ↗

Identification of Tumor Suppressive miR-144-5p Targets: FAM111B Expression Accelerates the Malignant Phenotypes of Lung Adenocarcinoma.Semantic proximity Read ↗

Genes suppressed by DNA methylation in non-small cell lung cancer reveal the epigenetics of epithelial-mesenchymal transition.Semantic proximity Read ↗

PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathwaySemantic proximity Read ↗

LncDBH-AS1 knockdown enhances proliferation of non-small cell lung cancer cells by activating the Wnt signaling pathway via the miR-155/AXIN1 axis.Semantic proximity Read ↗

SMAD4 mutation correlates with poor prognosis in non-small cell lung cancer.Semantic proximity Read ↗

Arkadia regulates tumor metastasis by modulation of the TGF-β pathway.Semantic proximity Read ↗

An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC developmentSemantic proximity Read ↗

MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherinSemantic proximity Read ↗

miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin geneSemantic proximity Read ↗

DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients.Semantic proximity Read ↗

RBM15 facilitates osimertinib resistance of lung adenocarcinoma through m6A-dependent epigenetic silencing of SPOCK1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.