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Article

Identification of Tumor Suppressive miR-144-5p Targets: FAM111B Expression Accelerates the Malignant Phenotypes of Lung Adenocarcinoma.

International journal of molecular sciences - 16 Sept 2024

Tomioka Yuya, Seki Naohiko, Suetsugu Takayuki, Hagihara Yoko, Sanada Hiroki, Goto Yusuke, Kikkawa Naoko, Mizuno Keiko, Tanaka Kentaro, Inoue Hiromasa

Abstract excerpt

Accumulating evidence suggests that the passenger strands microRNAs (miRNAs) derived from pre-miRNAs are closely involved in cancer pathogenesis. Analysis of our miRNA expression signature of lung adenocarcinoma (LUAD) and The Cancer Genome Atlas (TCGA) data revealed that miR-144-5p (the passenger strand derived from pre-miR-144) was significantly downregulated in LUAD tissues. The aim of this study was to...

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PMID: 39337462
DOI: 10.3390/ijms25189974
PMCID: PMC11432174

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