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Article

An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development

13 Oct 2021

Abstract excerpt

BACKGROUND: SETD1A, a member of SET1/MLL family H3K4 methyltransferases, is involved in the tumorigenesis of numerous cancers. However, the biological role and mechanism of SETD1A in non-small cell lung cancer (NSCLC) remain to be elucidated. METHODS: The expression of SETD1A, NEAT1, EZH2, and β-catenin in NSCLC tissues and cell lines was detected by qRT-PCR, immunohistochemistry and western blotting. The...

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PMID: 34645486
DOI: 10.1186/s13046-021-02119-x

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