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Article

miR-182 suppresses invadopodia formation and metastasis in non-small cell lung cancer by targeting cortactin gene

9 Jul 2018

Abstract excerpt

BACKGROUND: Metastasis is the leading cause of cancer mortality and is a major hurdle for lung cancer treatment. Invadopodia, which are cancer-specific protrusive structures, play a crucial role in the metastatic cascade through degradation of the basement membrane and surrounding stroma. Cortactin, a critical component of invadopodia, frequently used as an invadopodia marker, a universally important player in...

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PMID: 29986736
DOI: 10.1186/s13046-018-0824-1

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