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Article

Patients’ IgLON5 autoantibodies interfere with IgLON5-protein interactions

21 Mar 2023

Abstract excerpt

Background: Anti-IgLON5 disease is a rare neurological disorder characterized by autoantibodies against IgLON5, and pathological evidence of neurodegeneration. IgLON5 is a cell adhesion molecule but its physiological function is unknown. Our aim was to investigate the IgLON5 interactome and to determine if IgLON5 antibodies (IgLON5-abs) affect these protein interactions. Methods: IgLON5 interactome was...

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Identifiers

PMID: 37033996
DOI: 10.3389/fimmu.2023.1151574

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