Article
Using the power of genetic suppressors to probe the essential functions of RNase E.
Current genetics - 1 Feb 2016
Hughes Diarmaid
Abstract excerpt
This review describes how, using the power of genetic suppressor analysis, mRNA turnover in bacteria was shown to be an essential function of RNase E. RNase E is an essential multifunctional enzyme in bacteria, involved in the processing of stable RNAs to their mature forms (rRNAs and tRNAs) and in the turnover of most mRNAs. Genetic suppressor analysis was successfully used to address whether mRNA turnover is...
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