Article
Quasi-essentiality of RNase Y in Bacillus subtilis is caused by its critical role in the control of mRNA homeostasis.
Nucleic acids research - 9 Jul 2021
Benda Martin, Woelfel Simon, Faßhauer Patrick, Gunka Katrin, Klumpp Stefan, Poehlein Anja, Kálalová Debora, Šanderová Hana, Daniel Rolf, Krásný Libor, Stülke Jörg
Abstract excerpt
RNA turnover is essential in all domains of life. The endonuclease RNase Y (rny) is one of the key components involved in RNA metabolism of the model organism Bacillus subtilis. Essentiality of RNase Y has been a matter of discussion, since deletion of the rny gene is possible, but leads to severe phenotypic effects. In this work, we demonstrate that the rny mutant strain rapidly evolves suppressor mutations to...
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