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Article

An Epigenetic Mechanism of High Gdnf Transcription in Glioma Cells Revealed by Specific Sequence Methylation.

Molecular neurobiology - 1 Sept 2016

Zhang Bao-Le, Liu Jie, Lei Yu, Xiong Ye, Li Heng, Lin Xiaoqian, Yao Rui-Qin, Gao Dian-Shuai

Abstract excerpt

Glioma cells express high levels of GDNF. When investigating its transcriptional regulation mechanism, we observed increased or decreased methylation of different cis-acting elements in the gdnf promoter II. However, it is difficult to determine the contributions of methylation changes of each cis-acting element to the abnormally high transcription of gdnf gene. To elucidate the contributions of methylation...

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Source

Identifiers

PMID: 26232065
DOI: 10.1007/s12035-015-9365-1

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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