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Article

Changes in transcriptional factor binding capacity resulting from promoter region methylation induce aberrantly high GDNF expression in human glioma.

Molecular neurobiology - 1 Dec 2013

Yu Zheng-Quan, Zhang Bao-Le, Ren Qing-Xian, Wang Jian-Cun, Yu Ru-Tong, Qu De-Wei, Liu Ze-Hao, Xiong Ye, Gao Dian-Shuai

Abstract excerpt

Glial cell line-derived neurotrophic factor (GDNF), which belongs to transforming growth factor β superfamily, plays important roles in glioma pathogenesis. Gdnf mRNA is aberrantly increased in glioma cells, but the underlying transcription mechanism is unclear. Here, we found that although the base sequence in the promoter region of the gdnf gene was unchanged in glioma cells, there were significant changes in...

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Share to Brain Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

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Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 23606280
DOI: 10.1007/s12035-013-8443-5

Genes

GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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