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Article

Epigenetic regulation of glial fibrillary acidic protein by DNA methylation in human malignant gliomas

12 Nov 2010

Abstract excerpt

Glial fibrillary acidic protein (GFAP) is an intermediate filament expressed in glial cells that stabilizes and maintains the cytoskeleton of normal astrocytes. In glial tumors, GFAP expression is frequently lost with increasing grade of malignancy, suggesting that GFAP is important for maintaining glial cell morphology or regulating astrocytoma cell growth. Most permanent human glioma cell lines are GFAP...

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PMID: 21075782
DOI: 10.1093/neuonc/noq145

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