Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Old age genetically confirmed frontotemporal lobar degeneration with TDP-43 has limbic predominant TDP-43 deposition.

Neuropathology and applied neurobiology - 1 Dec 2021

Buciuc Marina, Whitwell Jennifer L, Baker Matthew C, Rademakers Rosa, Dickson Dennis W, Josephs Keith A

Abstract excerpt

AIMS: To assess the burden of transactive response DNA-binding protein of 43 kDa (TDP-43) inclusions in a unique cohort of old-age patients with genetic frontotemporal lobar degeneration (gFTLD-TDP) and compare these patients with sporadic old-age individuals with TDP-43, either in the presence of Alzheimer's disease (AD-TDP) or in isolation (pure-TDP). METHODS: The brain bank at Mayo Clinic-Jacksonville was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Frontotemporal Dementia

Share to Frontotemporal Lobar Degeneration

Share to Inclusion Bodies

Share to Neurofibrillary Tangles

Share to TDP-43 Proteinopathies

Source

Open in PubMed Open full text

Identifiers

PMID: 33969528
DOI: 10.1111/nan.12727
PMCID: PMC8576062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Old age genetically confirmed frontotemporal lobar degeneration with TDP-43 has limbic predominant TDP-43 deposition.PMID 33969528Read ↗

Frontotemporal-TDP and LATE Neurocognitive Disorders: A Pathophysiological and Genetic ApproachSemantic proximity Read ↗

TDP-43 and Limbic-Predominant Age-Related TDP-43 EncephalopathySemantic proximity Read ↗

Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management.Semantic proximity Read ↗

Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiologySemantic proximity Read ↗

A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP).Semantic proximity Read ↗

Concurrent tau pathologies in frontotemporal lobar degeneration with TDP-43 pathologySemantic proximity Read ↗

TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes.Semantic proximity Read ↗

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine.Semantic proximity Read ↗

TDP-43 Pathology in Alzheimer’s DiseaseSemantic proximity Read ↗

Frontotemporal lobar degeneration: Pathogenesis, pathology and pathways to phenotype.Semantic proximity Read ↗

Molecular subtyping based on hippocampal cryptic exon burden reveals proteome-wide changes associated with TDP-43 pathology across the spectrum of LATE and Alzheimer’s DiseaseSemantic proximity Read ↗

Data-driven neuropathological staging and subtyping of TDP-43 proteinopathiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.