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Colorectal cancer-derived extracellular vesicles induce transformation of fibroblasts into colon carcinoma cells

14 Jun 2019

Abstract excerpt

BACKGROUND: We reported that horizontal transfer of malignant traits to target cells is a potential pathway to explain cancer dissemination. Although these results were encouraging, they were never corroborated by data showing the molecular mechanisms responsible for the observed phenomenon. METHODS: In the present study, we exposed BRCA1-KO fibroblasts to extracellular vesicles (EVs) isolated from a colon cancer...

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PMID: 31200749
DOI: 10.1186/s13046-019-1248-2

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