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Article

Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells.

Oncotarget - 2 Aug 2016

Lugini Luana, Valtieri Mauro, Federici Cristina, Cecchetti Serena, Meschini Stefania, Condello Maria, Signore Michele, Fais Stefano

Abstract excerpt

BACKGROUND: Cancer cells, including colorectal cancer ones (CRC), release high amounts of nanovesicles (exosomes), delivering biochemical messages for paracrine or systemic crosstalk. Mesenchymal stromal cells (MSCs) have been shown to play contradicting roles in tumor progression. RESULTS: CRC exosomes induce in cMSCs: i) atypical morphology, higher proliferation, migration and invasion; ii) formation of...

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Identifiers

PMID: 27418137
DOI: 10.18632/oncotarget.10574
PMCID: PMC5226570

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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