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Stochasticity and Spatial Interaction Govern Stem Cell Differentiation Dynamics

31 Jul 2015

Abstract excerpt

Stem cell differentiation underlies many fundamental processes such as development, tissue growth and regeneration, as well as disease progression. Understanding how stem cell differentiation is controlled in mixed cell populations is an important step in developing quantitative models of cell population dynamics. Here we focus on quantifying the role of cell-cell interactions in determining stem cell fate....

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PMID: 26227093
DOI: 10.1038/srep12617

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